CD11c: Not merely a murine DC marker, but also a useful vaccination target
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منابع مشابه
Uric acid: a prognostic marker not only before but also after heart transplantation.
OBJECTIVES Early diagnosis of rejection after heart transplantation is mandatory, since even mild rejection can rapidly progress to more severe rejection. However, the identification of patients at high risk of acute cellular rejection and their non-invasive diagnosis remains a challenge. To identify patients with a high risk of acute cellular rejection during the first post-transplantation yea...
متن کاملC-reactive protein: not only a marker but also a mediator of myocardial damage following acute myocardial infarction.
I have greatly enjoyed reading the recently published article by Ørn et al. assessing the relationship between inflammatory mediators, including C-reactive protein, and indices of infarct size and left ventricular remodelling following successful primary percutaneous coronary intervention (PCI) in patients with first-time ST elevation myocardial infarction (MI). With improved understanding of t...
متن کاملHypoxia: not merely a regulator of angiogenesis?
Introduction Maintaining oxygen homeostasis is of vital importance for the survival and development of mammalian cells. Hypoxia (below-normal levels of oxygen in air, blood and tissue) can potentially lead to cellular dysfunction and ultimately cell death and is a feature of many pathological conditions. Understanding how reduced oxygen levels may contribute to or even promote disease is a sign...
متن کاملLipoprotein‐Associated Phospholipase A2 Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease
BACKGROUND We evaluated lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in patients with stable coronary heart disease before and during treatment with darapladib, a selective Lp-PLA2 inhibitor, in relation to outcomes and the effects of darapladib in the STABILITY trial. METHODS AND RESULTS Plasma Lp-PLA2 activity was determined at baseline (n=14 500); at 1 month (n=13 709); seria...
متن کاملC-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases.
Inflammatory processes play a pivotal role in the pathogenesis of atherosclerosis and mediate many of the stages of atheroma development from initial leukocyte recruitment to eventual rupture of the unstable atherosclerotic plaque. C-reactive protein (CRP), an acute phase reactant that reflects different degree of inflammation, has been indicated an independent risk factor in a variety of cardi...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2008
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.200838645